In vitro and in vivo degradation behavior of poly(trimethylene carbonate-co-d,l-lactic acid) copolymer

We present P(TMC-co-DLLA) copolymer with the molar ratio of TMC: DLLA = 15: 85 was used to systematic study of in vivo and in vitro degradation behaviors. Dense homogeneous copolymer specimens were prepared by compression molding method. The in vitro and in vivo degradation were, respectively, performed at simulative body condition and implanted into rat's subcutaneous condition. Investigations were followed via physicochemical and histological analysis such as SEM, GPC, DSC, FTIR and H&E stain. The results demonstrate that copolymeric material can degrade in phosphate buffer solution (PBS) and in rat's body, and the in vivo degradation rate is faster. Obvious decline of molecule weight and mass loss has been observed, which led to the attenuation of mechanical strength. Furthermore, apart from the hydrolysis, macrophagocytes took part in the phagocytosis in vivo, indicating that degradation rate could be regulated by the combinational mechanism. It is concluded that P(TMC-co-DLLA) copolymer is a promising candidate for tissue repair.